::This deviation is part of the colection FREAKS OF SCIENCE. [link]
After many years of research in the ubiquitination area, Prof Pezzino began to develop an agravated paranoia syndrome. He claimed he had been targeted for degradation and has been living a life of fear since then. He is ofter troubled with nightmares where he is chased by a demonic proteasome threating to kill him. Prof Pezzino showers three times per day to wash away the ubiquitin residues.
Inside the cells proteins are produced and degraded according needs. When proteins need to be quickly degraded they get ubiquitinated, i.e., a series of ubiquitine groups are added to the target protein, marking it to degradation. [link]
I often look at this mechanism as a small Mafia inside each cell. This is the whole basis of Dr Pezzinos joke. Of course he had to be Italian.